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Lorazepam is a powerful, precisely dosed, and rigorously regulated prescription medication that has a legitimate, well-defined, and potentially life-saving role in the short-term management of severe and disabling anxiety, the acute termination of panic attacks, the stabilization of acute alcohol withdrawal, the provision of preoperative sedation, and the emergent treatment of Status Epilepticus, but it is a medication that must be wielded with wisdom, with caution, with a clear and time-limited plan, and under the close and ongoing supervision of a qualified healthcare professional, due to its substantial and well-documented risks of tolerance, dependence, withdrawal, and respiratory depression when combined with other central nervous system depressants. Nordazepam is itself a potent and long-acting benzodiazepine agonist in its own right, and it possesses an extraordinarily long elimination half-life that can range from approximately forty to one hundred hours or even considerably longer in some individuals, particularly the elderly, those with genetic polymorphisms that result in slow CYP2C19 metabolizer status, and those with compromised hepatic function due to any cause. 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